A Pharmacokinetic Profile and Antihyperlipidemic Effectiveness of Nanoemulsion and Ethanol Extract from Parang Romang Leaves (Boehmeria virgata)

Background: Parang Romang has an antihyperlipidemic effect, but the use of herbs limitations with poor solubility in water, causing failure clinical phase due to low bioavailability. Bioavailability can be increased nanotechnology, one which is nanoemulsion. Objectives: This study aimed determine pharmacokinetic profile and effectiveness from nanoemulsion preparation ethanol extract parang romang leaves. Methods: Pharmacokinetic 10 rats each given 100 mg/kg BW The blood was taken at 0.5; 1; 1.5; 2; 2.5; 3; 3.5; 4 hours measure tmax, Cpmax, AUC. Study 30 divided into 5 groups normal control group I Na CMC suspension, II negative high fat feed + streptozotocin, III positive streptozotocin & simvastatin 0.9 mg/ kg BW, IV leaves V Then on day 0,14,21, 28 35. Results: results test showed that values ​​of AUC for nanoemulsions were respectively; 0.5 hours, 96.68 g/ml 297.57 1-hour, 15.44 93.53 statistical obtained a significant value (P < 0,05 ) effect between reduce cholesterol levels Conclusions: There are differences preparations extracts roman